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課程名稱 |
去氧核糖核酸損傷、修復、和癌症
DNA Damage, Repair, and Cancer |
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開課學期 |
111-2 |
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授課對象 |
生命科學院 生化科學研究所 |
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授課教師 |
冀宏源 |
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課號 |
BChem5047 |
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課程識別碼 |
B46 U1070 |
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班次 |
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學分 |
2.0 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期一6,7(13:20~15:10) |
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上課地點 |
新204 |
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備註 |
與李弘文、詹迺立、林敬哲、吳青錫、張智芬合授
總人數上限：60人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
In this course, we will discuss the sources of DNA damage and how cells sense and respond to DNA lesions. Multiple DNA repair pathways, their discovery histories and new technologies for measuring DNA damages and repair will be covered in the lectures. Our genome integrity is maintained by a multitude of DNA repair and DNA damage response mechanisms. The failure of these mechanisms can result in a variety of diseases including cancer. The application of DNA damage and repair in therapeutic intervention in cancer and genome editing will be also introduced. |
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課程目標 |
Through this course, students will be familiar with the fundamental knowledge of DNA damage, repair, and cancer. In addition, students will learn the classical and advanced methodology to study DNA damage and repair. We will also motivate students to ask questions and engage them to participate in the discussion. |
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課程要求 |
We encourage students to take Biochemistry course before attending this class. |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
1. Genome Stability, James E. Haber, 2014
2. Advanced review articles from each session |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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第1週 |
2/20 |
I. DNA Damages and Repair systems
林敬哲老師
DNA damage sources and mutations |
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第2週 |
2/27 |
調整放假 |
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第3週 |
3/06 |
冀宏源老師
DNA repair systems |
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第4週 |
3/13 |
林敬哲老師
DNA repair systems |
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第5週 |
3/20 |
冀宏源老師
Crosstalk between repair pathways |
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第6週 |
3/27 |
II. Biophysical, Imaging and Structural Approaches to study DNA repair mechanisms
李弘文老師
Tools to study protein-DNA binding |
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第7週 |
4/03 |
調整放假 |
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第8週 |
4/10 |
Examination (紙筆考試) |
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第9週 |
4/18 |
詹迺立老師
Structural basis of nucleic acids processing |
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第10週 |
4/24 |
詹迺立老師
Structural basis of DNA repair machineries |
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第11週 |
5/01 |
李弘文老師
Single-molecule imaging tools |
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第12週 |
5/08 |
李弘文老師&詹迺立老師
Session II discussion |
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第13週 |
5/15 |
III. DNA Repair and Cancer
吳青錫老師
Sensing DNA damage and the signal response |
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第14週 |
5/22 |
吳青錫老師
DNA damage response and cancer |
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第15週 |
5/29 |
張智芬老師
Genome instability of cancer |
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第16週 |
6/05 |
張智芬老師
DNA damage and repair in cancer therapy |
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第17週 |
6/12 |
吳青錫老師&張智芬老師
Session III discussion |
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